Fluharty Industries


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Thursday April 17, 2014 Re: Don’t Forget To Write!

1. Toby gets springer from jail Saturday. I miss the little guy. I do find relief sometimes not having to worry about him barking while i go out of the apartment or leaving the door open while stepping out. I suppose I just wish he didn’t bark as much. Even though Jackie never barked I didn’t leave the apartment as much.

2. Recently I have always felt better after talking to Ian about Wolff HomeCare. It is all going we’ll I suppose because I went through Ian every step of the way.

3. I ordered Dads Birthday present today and got my bills up to date.


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March 20, 2014 I am starting a private like journal.

I think this may be private with the option of allowing invited guests to view your journal. I would like to have a public blog as my journal but most of what i would like to write about is sensitive in nature and not fit for public viewing.

This entry above this text came from an email and looks good. I wonder how replying to the email reminders will end up looking like. And then this edit came from my iPad.

####UPDATE###

this is from my old journal and I have switched to wordpress.


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March 21, 2014 Entrepreneur thoughts

From Steve Jobs via Guy Kawasaki Use a top ten bullet format for speeches any more bullets is arrogant and superfluous You will suck and go long. Proving your stupid and arrogant. @ Experts are clueless if someone claims to be a guru or expert then run for the hills. They will tend to tell you the norm and inhibit ground breaking innovation. Avoid self proclaimed experts or gurus. @ Customers can not tell you what they need. They inhibit innovation because they refer to current trends and technology to tell you their needs. You can ask them with assisting in evolution to improve current things. But not how to create a revolution. Need and want are two different things. The customer can tell you what they want but it is up to you to provide what they didn’t even know what they needed. @ biggest challenges beget the best work. Give you team a huge challenge and use you team as a brain trust/ tank. Enable your team to be able to come through with the challenge. @ Design counts. Sir John Ives is an example. Steve always gave examples of his father going the extra effort for things not always seen like the back side of a fence or cabinet against the wall. @ big graphics and big fonts. In presentations. @ jump curves, not better sameness. Don’t settle for doing something 10% better do them 10 or 100 times better


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March 21, 2014 Friday

I got an offer in the email today for a video journal program. it was only ten bucks but i didn’t think it integrated the video enough to make it worth anything.

Penzu didn’t send me an update reminder.

dent bother me much because penzu is only 20 bucks a year and you get what you pay for.

this journaling technique can’t use video, only photograph images.

I ordered an SSD installation kit for my  iMac last night. It has the hardware and tools. I don’t mind switching an SSD for the optical drive but if there is an open internal drive bay i would rather use it.

http://wwwapps.ups.com/WebTracking

today my Psychologist had a session.it was calm because private duty is, has taken over for the attendant duty.

I will be able to go into detail about the private duty situation in this set of journals.


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April 14, 2014 Amazon offers warehouse workers up to $5,000 to quit

TECHNOLOGY – APRIL 11, 2014 3:02AM

Amazon has moved to hire thousands of additional workers at its warehouses across the U.S.

GET CIRCA NEWS
Copyright 2014 Reuters

COPYRIGHT 2014 REUTERS

1

In his annual letter to shareholders (publicly released on April 10), Amazon CEO Jeff Bezos revealed a program called “Pay to Quit” in which the company offers to pay its warehouse staff up to $5,000 to quit their job. “We hope they don’t take the offer,” Bezos claimed.

2
 

“Once a year, we offer to pay our associates to quit… Why do we make this offer? The goal is to encourage folks to take a moment and think about what they really want. In the long-run, an employee staying somewhere they don’t want to be isn’t healthy for the employee or the company.”JEFF BEZOS, AMAZON CEO

Bezos credited Zappos, which Amazon acquired in July 2009, for devising the program.

3

Amazon in the past several months has announced plans to hire several thousand workers at warehouse in states like Washington, Kansas, South Carolina, and Tennessee. Amazon has said that it has added more than 40,000 full-time jobs throughout the company since September 2008.

 


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April 21, 2014 Why Weed Makes You… You… Huh?

Why Weed Makes You... You... Huh?SEXPAND

Scientists have long suspected that THC somehow affects the hippocampus region of the brain, the bit responsible for controlling short-term memory, but they have never been able to prove it. Turns out that’s because they were looking at the wrong grey matter.

A duo of researchers—Giovanni Marsicano of the University of Bordeaux, France, and Xia Zhang of the University of Ottawa Institute of Mental Health Research—have been credited with the discovery, published in the journal Cell. Previously, scientists believed that THC “loosened” synapses in the hippocampus, resulting in memory loss. But, contrary to convention, the effect isn’t rooted in the drug’s effect on the neurons alone but also on an undiscovered reaction between THC and non-neuronal cells known as astrocytes.

Astrocytes used to be thought of simply “support” cells that helped neurons function. However, the team’s research showed that these cells also produce a chemical called AMPA when they interact with THC and it’s the AMPA compound that can mitigate or enhance the looseness of the neuron’s synapse.

To prove the hypothesis, the team employed three types of rats with various alterations to their neurons’ CB1 receptors (these receptors bind with THC and activate the cells when THC is present). The first set lacked receptors on cells that produce the neurotransmitter glutamate, the second set lacked receptors on cells that create the neurotransmitter GABA, and the third set lacked them on the AMPA-producing astrocytes. Basically, if the cells lacked this receptor, THC wouldn’t affect them and they wouldn’t produce the associated chemical.

The team inserted electrodes into the anesthetized rats’ brains, got them blunted, and then recorded the results. The glutamate and GABA sets of rats responded in the same way that normal rats would—high as shit and terrible short-term memory. The AMPA-less rats however were unaffected.

So hey, great, they’ve figured out how to get rats high but not forget what they were just doing. How does that affect the average toker in the street? It’s actually kind of a big deal, since science had no clue that astrocytes did much more than sit there. It opens up an entire new avenue of neuroresearch and Marsicano envisions this discovery leading to THC-derived pain-killers that don’t affect working memory—think Ambien without all the pesky sleep-driving.

And for tokers looking to take advantage of this discovery—right now, before you forget—should check with their local dispensary for strains containing high concentrations of cannabidiol. A 2010 study noted that strains high in it didn’t produce the impairing side effect. [Nature]

Image: Paul Prescott / Shutterstock


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April 21, 2014 Blue Light Affects Sleep (and here’s why)

Trouble sleeping?

If you have sleep trouble or you’re trying to learn more about sleep in general, we recommendunderstandingsleep.org.

AMA Report

In 2012, the American Medical Association’s Council on Science and Public Health made this recommendation:

“Recognizes that exposure to excessive light at night, including extended use of various electronic media, can disrupt sleep or exacerbate sleep disorders, especially in children and adolescents. This effect can be minimized by using dim red lighting in the nighttime bedroom environment.”

Blue Light Affects Sleep (and here’s why)

We know that night-time exposure to blue light keeps people up late. We believe that f.lux adjusts colors in a way that greatly reduces the stimulating effects of blue light at night.

To understand the effects of f.lux on sleep, we’ve spoken with some researchers, and we’ve read a whole lot of papers.

The science that explains why blue light keeps you up was begun many years ago in the study of bird migration, and it continued in humans with the discovery of a new photoreceptor in the eye, called Melanopsin. Many are familiar with the “rods and cones” that provide our visual capabilities, but it was only about 15 years ago that retinal ganglion cells containing melanopsin, which are sensitive to a narrow band of blue light in the 460-480nm range, were discovered, and their unique effect on sleep was investigated.

The experimental research suggests that an average person reading on a tablet for a couple hours before bed may find that their sleep is delayed by about an hour. Clearly, the details are complicated, but that’s why we get to cite so many very interesting papers.

Popular press coverage of blue light research

In Eyes, a Clock Calibrated by Wavelengths of Light cites work by Cajochen et al in the May issue of The Journal of Applied Physiology.

Christian Cajochen did the first work we know of that uses real LED displays and measures them against older computer monitors. Many studies before this used light sources that you could believe were “like” these newer displays, but this paper tests the exact kind of backlight that we all use many hours a day.

Blue Light

David C. Holzman does a survey paper on the effects of blue light, with citations as early as 1958.

What’s in a Color? The Unique Human Health Effects of Blue Light Holzman DC 2010. What’s in a Color? The Unique Human Health Effects of Blue Light. Environ Health Perspect 118:A22-A27. doi:10.1289/ehp.118-a22

NIH-Funded research

NIH-funded research is available in its full text online. If you’ve tried to search for journal articles and read them online, you know that a large number of scientific journals today are difficult to access, except from within an institution that subscribes. The following bibliography includes the NIH-published versions of some of the work done at Brigham and Women’s Hospital (Harvard Medical School).

Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans Joshua J. Gooley, Kyle Chamberlain, Kurt A. Smith, Sat Bir S. Khalsa, Shantha M. W. Rajaratnam, Eliza Van Reen, Jamie M. Zeitzer, Charles A. Czeisler, Steven W. Lockley J Clin Endocrinol Metab. 2011 March; 96(3): E463–E472. Published online 2010 December 30. doi: 10.1210/jc.2010-2098

The human circadian system adapts to prior photic history Anne-Marie Chang, Frank A J L Scheer, Charles A Czeisler J Physiol. 2011 March 1; 589(Pt 5): 1095–1102. Published online 2011 January 10. doi: 10.1113/jphysiol.2010.201194 PMCID: PMC3060589

High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. Lockley SW, Brainard GC, Czeisler CA. J Clin Endocrinol Metab. 2003 Sep;88(9):4502-5. PMID: 12970330 [PubMed – indexed for MEDLINE]

Effect of Light on Human Circadian Physiology Jeanne F. Duffy, Charles A. Czeisler. Sleep Med Clin. Author manuscript; available in PMC 2010 June 1. Published in final edited form as: Sleep Med Clin. 2009 June; 4(2): 165–177. doi: 10.1016/j.jsmc.2009.01.004 PMCID: PMC2717723

Suppression of melatonin secretion in some blind patients by exposure to bright light. Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF 3rd. N Engl J Med. 1995 Jan 5;332(1):6-11. PMID: 7990870 [PubMed – indexed for MEDLINE]

A phase response curve to single bright light pulses in human subjects Sat Bir S Khalsa, Megan E Jewett, Christian Cajochen, Charles A Czeisler J Physiol. 2003 June 15; 549(Pt 3): 945–952. Published online 2003 April 25. doi: 10.1113/jphysiol.2003.040477 PMCID: PMC2342968

Amplitude Reduction and Phase Shifts of Melatonin, Cortisol and Other Circadian Rhythms after a Gradual Advance of Sleep and Light Exposure in Humans Derk-Jan Dijk, Jeanne F. Duffy, Edward J. Silva, Theresa L. Shanahan, Diane B. Boivin, Charles A. Czeisler PLoS One. 2012; 7(2): e30037. Published online 2012 February 17. doi: 10.1371/journal.pone.0030037

Sex difference in the near-24-hour intrinsic period of the human circadian timing system Jeanne F. Duffy, Sean W. Cain, Anne-Marie Chang, Andrew J. K. Phillips, Mirjam Y. Münch, Claude Gronfier, James K. Wyatt, Derk-Jan Dijk, Kenneth P. Wright, Jr., Charles A. Czeisler Proc Natl Acad Sci U S A. 2011 September 13; 108(Supplement_3): 15602–15608. Published online 2011 May 2. doi: 10.1073/pnas.1010666108

Uncovering Residual Effects of Chronic Sleep Loss on Human Performance Daniel A. Cohen, Wei Wang, James K. Wyatt, Richard E. Kronauer, Derk-Jan Dijk, Charles A. Czeisler, Elizabeth B. Klerman Sci Transl Med. Author manuscript; available in PMC 2010 July 13. Published in final edited form as: Sci Transl Med. 2010 January 13; 2(14): 14ra3. doi: 10.1126/scitranslmed.3000458 PMCID: PMC2892834

The Impact of Sleep Timing and Bright Light Exposure on Attentional Impairment during Night Work Nayantara Santhi, Daniel Aeschbach, Todd S. Horowitz, Charles A. Czeisler J Biol Rhythms. Author manuscript; available in PMC 2009 August 1. Published in final edited form as: J Biol Rhythms. 2008 August; 23(4): 341–352. doi: 10.1177/0748730408319863 PMCID: PMC2574505

Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina Farhan H. Zaidi, Joseph T. Hull, Stuart N. Peirson, Katharina Wulff, Daniel Aeschbach, Joshua J. Gooley, George C. Brainard, Kevin Gregory-Evans, Joseph F. Rizzo, III, Charles A. Czeisler, Russell G. Foster, Merrick J. Moseley, Steven W. Lockley. Curr Biol. 2007 December 18; 17(24): 2122–2128. doi: 10.1016/j.cub.2007.11.034 PMCID: PMC2151130

Entrainment of the human circadian pacemaker to longer-than-24-h days Claude Gronfier, Kenneth P. Wright, Jr., Richard E. Kronauer, Charles A. Czeisler Proc Natl Acad Sci U S A. 2007 May 22; 104(21): 9081–9086. Published online 2007 May 14. doi: 10.1073/pnas.0702835104 PMCID: PMC1885631

Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects Jeanne F. Duffy, Jamie M. Zeitzer, Charles A. Czeisler Neurobiol Aging. Author manuscript; available in PMC 2008 May 1. Published in final edited form as: Neurobiol Aging. 2007 May; 28(5): 799–807. Published online 2006 April 18. doi: 10.1016/j.neurobiolaging.2006.03.005 PMCID: PMC1855248

Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans Claude Gronfier, Kenneth P. Wright, Richard E. Kronauer, Megan E. Jewett, Charles A. Czeisler Am J Physiol Endocrinol Metab. Author manuscript; available in PMC 2009 October 14. Published in final edited form as: Am J Physiol Endocrinol Metab. 2004 July; 287(1): E174–E181. Published online 2004 March 23. doi: 10.1152/ajpendo.00385.2003 PMCID: PMC2761596

Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans Kenneth P. Wright, Claude Gronfier, Jeanne F. Duffy, Charles A. Czeisler J Biol Rhythms. Author manuscript; available in PMC 2009 July 27. Published in final edited form as: J Biol Rhythms. 2005 April; 20(2): 168–177. doi: 10.1177/0748730404274265 PMCID: PMC2714089

Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression Jamie M Zeitzer, Derk-Jan Dijk, Richard E Kronauer, Emery N Brown, Charles A Czeisler J Physiol. 2000 August 1; 526(Pt 3): 695–702. doi: 10.1111/j.1469-7793.2000.00695.x PMCID: PMC2270041

Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans Kenneth P. Wright, Jr., Rod J Hughes, Richard E. Kronauer, Derk-Jan Dijk, Charles A. Czeisler Proc Natl Acad Sci U S A. 2001 November 20; 98(24): 14027–14032. doi: 10.1073/pnas.201530198 PMCID: PMC61161

Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure J F Duffy, R E Kronauer, C A Czeisler J Physiol. 1996 August 15; 495(Pt 1): 289–297. PMCID: PMC1160744

Temporal dynamics of late-night photic stimulation of the human circadian timing system Zeitzer JM, Khalsa SB, Boivin DB, Duffy JF, Shanahan TL, Kronauer RE, Czeisler CA. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R839-44. Epub 2005 May 12. PMID: 15890792 [PubMed – indexed for MEDLINE]

Adaptation of human pineal melatonin suppression by recent photic history Smith KA, Schoen MW, Czeisler CA. J Clin Endocrinol Metab. 2004 Jul;89(7):3610-4. Erratum in: J Clin Endocrinol Metab. 2005 Mar;90(3):1370. PMID: 15240654 [PubMed – indexed for MEDLINE]

Dynamic resetting of the human circadian pacemaker by intermittent bright light. Rimmer DW, Boivin DB, Shanahan TL, Kronauer RE, Duffy JF, Czeisler CA. Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1574-9. PMID: 11049838 [PubMed – indexed for MEDLINE]

Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients. Jewett ME, Rimmer DW, Duffy JF, Klerman EB, Kronauer RE, Czeisler CA. Am J Physiol. 1997 Nov;273(5 Pt 2):R1800-9. PMID: 9374826 [PubMed – indexed for MEDLINE]

Exposure to bright light and darkness to treat physiologic maladaptation to night work. Czeisler CA, Johnson MP, Duffy JF, Brown EN, Ronda JM, Kronauer RE. N Engl J Med. 1990 May 3;322(18):1253-9. PMID: 2325721 [PubMed – indexed for MEDLINE]

Mental activation and sleep

Some EEG studies of color effect on the brain have been done. One of the earlier ones we found is cited here.

From Effect of Illuminance and Color Temperature on Lowering of Physiological Activity, Noguchi H, Sakaguchi T.

“…we surmise that the effect of color temperature is greater than that of illuminance in an ordinary residential bedroom or similar environment where a lowering of physiological activity is desirable, and we therefore find the use of low color temperature illumination more important than the reduction of illuminance. Subjective drowsiness results also indicate that reduction of illuminance without reduction of color temperature should be avoided.”

These results suggest that low color temperature light creates a smooth lowering of central nervous system activity, and that low color temperature illumination can be used effectively in a bedroom or other such environment where it is desirable to facilitate lowered physiological activity.


From Effect of Color Temperature of Light Sources on Slow-wave Sleep”, Tomoaki Kozaki [1], Shingo Kitamura [2], Yuichi Higashihara [2], Keita Ishibashi [1], Hiroki Noguchi [3] and Akira Yasukouchi [1]

1. Department of Physiological Anthropology, Faculty of Design, Kyushu University 2. Department of Ergonomics, Kyushu Institute of Design 3. Matsushita Electric Works, Ltd.

Seven healthy males were exposed to the light sources of different color temperatures (3000 K, 5000 K and 6700 K) for 6.5 h before sleep. The horizontal illuminance level was kept at 1000 lux. Subjects slept on a bed in near darkness (<10 lux) after extinguishing the light, and polysomnograms recorded the sleep parameters. In the early phase of the sleep period, the amount of stage-4 sleep (S4-sleep) was significantly attenuated under the higher color temperature of 6700 K compared with the lower color temperature of 3000 K. Present findings suggest that light sources with higher color temperatures may affect sleep quality in a view that S4-sleep period is important for sleep quality.

Empirical performance studies

There is tons of research on human performance based on sleep, and some interesting research based on mental activation (and productivity) when cooler light colors are used in the work environment.

From http://www.jcircadianrhythms.com/content/5/1/2 “The effect of high correlated colour temperature office lighting on employee wellbeing and work performance”, Peter R Mills (1,2) , Susannah C Tomkins (1) and Luc JM Schlangen (3)

1. Vielife Ltd, 68 Lombard Street, London EC3V 9LJ, UK 2. Department of Respiratory Medicine, The Whittington Hospital, London N19 5NF, UK 3. Philips Lighting, Global Organisation Applications Lighting, P.O. Box 80020, 5600JM Eindhoven, The Netherlands Journal of Circadian Rhythms 2007, 5:2doi:10.1186/1740-3391-5-2

The amount of blue light in the spectrum of light sources increases with increasing colour temperature. So far a number of studies have investigated the effects of the colour temperature of lighting on mental activity, the central nervous system and alertness. These studies have demonstrated that higher colour temperatures (7500 K versus 3000 K) are more activating from the viewpoint of mental activity level [12]. Both the parasympathetic and sympathetic nervous systems are thought to be enhanced under higher colour temperature conditions. [13] and drowsiness has been observed to be higher under lower colour temperature lighting when comparing 3000 K with 5000 K [14].


From http://www.springerlink.com/content/g0882155n2838807/ “Effects of indoor lighting (illuminance and spectral distribution) on the performance of cognitive tasks and interpersonal behaviors: The potential mediating role of positive affect”

In Study 2, subjects exposed to warm white light reported stronger preferences for resolving interpersonal conflicts through collaboration and weaker preferences for resolving conflicts through avoidance than subjects exposed to cool-white light. Additionally, illuminance and spectral distribution (color) interacted to influence subjects’ self-set goals on a clerical coding task. In Study 3, receipt of a small, unexpected gift and exposure to warm-white light both increased the amount of time subjects were willing to donate as unpaid volunteers. In addition, in the absence of a gift, subjects volunteered more time under low than under high illuminance.

General blue light notes

Terman and Terman report in “Light Therapy for Seasonal and Nonseasonal Depression: Efficacy, Protocol, Safety, and Side Effects” in CNS Spectrums:

Recent attention has focused on the blue region, which actively suppresses melatonin production (23) and elicits circadian rhythm phase shifts. (24, 25) In a comparison of blue light with red light of lower intensity (designed as a placebo control), the antidepressant response to blue was superior, similar to that seen for white light in other studies. (26)

23. Brainard GC, Hanifin JP, Greeson JM, et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci. 2001;21:6405-6412.

24. Wright HR, Lack LC, Kennaway DJ. Differential effects of light wavelength in phase advancing the melatonin rhythm. J Pineal Res. 2004;36:140-144.

25. Warman VL, Dijk DJ, Warman GR, Arendt J, Skene DJ. Phase advancing human circadian rhythms with short wavelength light. Neurosci Lett. 2003;342:37-40.